Complementing our protein-level data, Arora et al. recently analyzed HNSCC tumor samples by spatial transcriptomics and demonstrated a significant enrichment of CD8+ T cells (adjusted p < 0.01) at the tumor’s leading edge, coincident with elevated CXCL10 mRNA expression in these regions compared to the tumor core [49]. The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.