Their findings on PCOS GCs demonstrated that promoter DNAme affects miRNA loci’s activities, with the hyper-DNAmes of miR-10b-5p, miR-127-3p, miR-23a-3p, and others suppressing miRNA output and derepressing apoptosis and stress-related targets, such as PTEN, MMP13, APAF1, and TET3 [11]. This evidence concerns the gene APAF1 and polycystic ovary syndrome.