In a diseased state, hair follicles from alopecia areata (AA) lesions display increased danger ligands; MHC Class I and Class II proteins with self-antigen presentation and pro-inflammatory cytokines like IFN-y and IL-15.56 CD8+ and CD4+ T cells also infiltrate the hair follicle, establishing the characteristic “swarm of bees” appearance in alopecia areata, keeping the HFSC in a state of quiescence, and effectively preventing the anagen stage [57]. This evidence concerns the gene CD4 and alopecia areata.