Finally, it has not escaped our notice that many of the key functions associated with RNF213, such as lipid metabolism, lipid droplet association, tumor development, and bacterial and viral endocytosis and regulation, are also features of Cav-1 functionality, and so it would not be unexpected to find these processes to be also mediated by this RNF213–Cav-1 axis. This evidence concerns the gene RNF213 and neoplasm.