Our novel findings of their interactions, and on the consequences of the ubiquitination and phosphorylation of Cav-1 by RNF213 on possible downstream signaling events, not only provide further insights into their functions but may also lead to the elucidation of the pathophysiological mechanisms underlying the various cellular events above as well as the onset and development of vasculopathies, such as MMD. The gene discussed is CAV1; the disease is vascular disorder.