Importantly, mouse xenograft experiments showed that decreased RacGAP1 expression significantly reduced tumor growth, paralleled by a decreased expression of some pluripotency-related and cell cycle-related genes, thus validating the bioinformatic selection of RacGAP1 as a hub gene of the high stemness score group of LUAD patients and closely correlated with poor prognosis [29]. The gene discussed is RACGAP1; the disease is neoplasm.