AKT1 and laryngotracheoesophageal cleft: With regard to LC, very recently, RacGAP1 has been found to be upregulated in tumor samples and associated with the PI3K/AKT signaling pathway in the regulation of cell proliferation [28,29,30]; however, the clinical significance of RacGAP1 overexpression and mechanistic insights on how it is involved in pathways driving lung cancer are still largely unknown.