The Wnt ligands Wnt2B and Wnt5A, secreted glycoproteins interacting with the transmembrane receptors FZD/LRPs (Frizzleds/Low-density lipoprotein receptor-related proteins), are known to play a pivotal role in the regulation of signaling and their aberrant expression has been found to be closely correlated with the occurrence and progression of LC [40]. The gene discussed is WNT5A; the disease is laryngotracheoesophageal cleft.