ScRNAseq analysis of symptomatic (recent stroke or myocardiac infarction, MI), compared to asymptomatic, plaques revealed that CD4+ T-cells in asymptomatic patients displayed activation and effector functions (e.g., IFNγ pathway) and upregulated IL-1 and IL-6 pathways, while T-cells from symptomatic subjects did not activate IL-1 and IL-6 pathways, but upregulated pathways associated with T-cell migration (e.g., RhoGTPase pathway) and differentiation (e.g., Wnt signalling and IL-2 signalling pathways). Here, IL6 is linked to Stroke.