TPO and Sepsis: Shimizu, et al. [215] noted a substantial increase in IL-6 and TPO, both pleiotropic cytokines capable of driving platelet hyper-responsiveness in sepsis-related DIC patients, and demonstrated that the addition of IL-6 and TPO enhanced the release of soluble CD40L (sCD40L) and platelet-derived microparticles (PDMP), facilitating increased platelet–endothelial and platelet–leukocyte interactions.