Using Mendelian randomisation principles, in which genetic variants can be assessed for their causal relationship with observed phenotypes, Swerdlow, et al. [191] conducted a meta-analysis of 34 studies and described an IL6R rs7529229 SNP, which resulted in an increase in sIL-6R and a significantly decreased risk of coronary heart disease events [129]. Here, IL6R is linked to coronary artery disorder.