Remarkably, the transcriptomic analysis revealed that ovarian cancer patients with low NKX3-2/high TP53 expression display a marked downregulation of a wide range of genes related to oncogenic hallmarks (e.g., apoptosis evasion, cell migration, macromolecule biosynthetic processes, etc.)in parallel to an upregulation of several transcripts involved in DNA damage checkpoints, mitochondrial respiration, and proteolysis. The gene discussed is NKX3-2; the disease is ovarian carcinoma.