However, for those with high-risk conditions such as type 2 diabetes mellitus (T2D), notable decreases were observed in the frequency of classical monocytes (CD14Hi CD16−), along with a more pronounced case of lymphocytopenia in patients with T2D, with 1.6 times fewer CD8+ lymphocytes in those requiring critical care [55]. This evidence concerns the gene CD8A and type 2 diabetes mellitus.