CD40LG and infection: The interplay between these pathways and the presence of growth factors such as PDGF-AA (Platelet-Derived Growth Factor-AA), PDGF-AB-BB (two isoforms), FGF-2 (Fibroblast Growth Factor 2), and soluble CD40L in the plasma of infected patients contributes to vessel remodeling, angiogenesis, and the pathogenesis of severe diseases, highlighting the intricate relationship between infection, immune responses, and host cell alterations [23,24].