AKT1 and hydrops fetalis: Intriguingly, the PI3K/Akt/mTOR signaling pathway was enriched by 33% and that of the protein kinase mechanistic target of rapamycin complex 1 (mTORC1), which is involved in cell growth and cell survival [37] and has been shown to be activated by cholesterol [37], was enriched by 86% in the HF-fed LFABP−/− mice relative to WT (Table 2).