Smaller adipocytes are thought to be more insulin-sensitive [9,16,50,52]; thus, the effect of Lfabp ablation on the quality of sWAT may contribute to the previously reported MHO phenotype of the LFABP−/− mouse, which is characterized by normal plasma glucose and insulin levels despite marked obesity [3]. This evidence concerns the gene FABP1 and obesity due to melanocortin 4 receptor deficiency.