Interestingly, we found an approximately 3.5-fold downregulation of cytochrome P450 family 2 subfamily E member 1 (Cyp2e1), characteristic of adipogenesis regulator (Areg) cells that inhibit adipogenesis through the retinoic acid signaling pathway [32], as well as those of family with sequence similarity 13 member A (Fam13a), implicated in adipocyte size and fat distribution [33], in the iWAT of HF-fed LFABP−/− mice relative to WT. This evidence concerns the gene CYP2E1 and hydrops fetalis.