Our findings in HF-fed LFABP−/− mice, which overexpress Sdc4, are consistent with these results, since we find a marked decrease in the size of inguinal adipocytes; decreased expression and staining of F4/80, indicative of lower macrophage infiltration; and normal glycemic and lipidemic profiles despite massive adiposity, as previously reported [3]. This evidence concerns the gene SDC4 and hydrops fetalis.