Noncanonical NF-κB signaling can be stimulated after lipopolysaccharide (LPS) binding to Dectin1 and TNFR2 and can be initiated by TNFR2 and TNFRSFs (TNFR superfamily members) such as TNFRSF12a, which is significantly enriched in the iWAT of HF-fed LFABP−/− mice. The gene discussed is TNFRSF1A; the disease is hydrops fetalis.