The transcriptomic profile of iWAT reveals that, among the ECM components, levels of several collagens (Col1a1, Col1a2, Col3a1), along with Postn (periostin), Lama2 (laminin α-2 chain), Spp1 (osteopontin), and Ecm1 (extracellular matrix protein 1), are significantly downregulated, whereas Thbs1 (thrombospondin-1) is significantly upregulated in HF-fed LFABP−/− mice relative to WT (Figure 8a). The gene discussed is SPP1; the disease is hydrops fetalis.