In MCF-7 breast cancer cells, nickel-doped Co ferrite nanoparticles have been reported to induce apoptosis by increasing ROS generation, downregulating Bcl-2 expression, and upregulating p53, Bax, as well as cleaved caspase-3, -8, and -9 protein levels [66]. The gene discussed is CASP3; the disease is breast carcinoma.