For example, paclitaxel-loadedMSNs showed increased cytotoxicity against HepG2 liver carcinoma cells,achieving a significantly lower IC50 compared with paclitaxelsolution. Additionally, codelivery ofcamptothecin and survivin using PEGylated MSNs enhanced cytotoxicityand induced apoptosis in C26 colorectal cancer cells. However, in vitro assays present limitationsconcerning the treatment times and drug concentrations; thus, theantitumor efficacy of IVM-NC cannot be dismissed compared with IVM-MCMand IVM treatments. Here, BIRC5 is linked to hepatocellular carcinoma.