IFNG and infection: Notably, a significantly lower C. parvum infection burden was observed in IFN-γ-pretreated IEC4.1-Prdm1−/− cells compared with IFN-γ-pretreated IEC4.1 cells (Fig. 8A), indicating an enhanced inhibition of infection by IFN-γ in IEC4.1-Prdm1−/− cells.