NPPB and cardiac hypertrophy: In a mouse model of cardiac hypertrophy and fibrosis, observation was made regarding the upregulation of HDAC8 leading to an increase in the expression of cardiac hypertrophy‐related genes, such as natriuretic peptide A (NPPA), NPPB, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), through the activation of the p38 MAPK signalling pathway.