Another study also found that HDAC1 expression was reduced in an animal model of atherosclerosis and found that overexpression of HDAC1 enhanced the effect of miR‐222‐3p targeting Fos‐like antigen 2, thereby inhibiting vascular endothelial cell apoptosis through deacetylating hypoxia‐inducible factor‐1α [62]. This evidence concerns the gene HDAC1 and atherosclerosis.