GLP1R and obesity due to melanocortin 4 receptor deficiency: Search terms included combinations of “bariatric surgery,” “GLP-1 receptor agonists,” “semaglutide,” “tirzepatide,” “anti-obesity medications,” and “obesity management.” We included clinical trials, meta-analyses, reviews, and relevant opinion pieces that addressed the efficacy, safety, economic impact, and professional implications of both surgical and pharmacologic obesity treatments.