Previous experiments in vivo have shown that a combined treatment of TRAIL with a ferroptotic agent, such as anti-malarial agent, artesunate (ART), synergistically enhances apoptosis in cancer cell lines via the crosstalk between the ferroptotic agent-induced endoplasmic reticulum (ER) stress pathway and the intrinsic Bid–Bax mitochondrial-dependent apoptosis pathway [7,9,13,14]. This evidence concerns the gene BID and cancer.