Downregulation of TLR5 has been shown to promote proliferation, metastasis, and epithelial-to-mesenchymal transition (EMT) in triple-negative breast cancer (TNBC), whereas high TLR5 expression is linked to diminished metastatic potential and favorable clinical outcomes (Shi et al., 2019). The gene discussed is TLR5; the disease is triple-negative breast carcinoma.