MECP2 and Rett syndrome: Such studies employ several strategies, such as routinely reanalyzing existing genomic data, repeating genetic testing as new technologies emerge, and evaluating the existing RTT individuals reported with variants in genes other than MECP2, CDKL5, and FOXG1. In this context, we report an individual clinically diagnosed with atypical RTT, with a pathogenic variant in the chromodomain-helicase-DNA-binding protein 8 (CHD8) gene.