SCNN1B and lung disorder: While CFTR mutated mice do not exhibit features of lung disease (Lewis et al., 2019), the Scnn1b-Tg+ mouse overexpresses sodium channel, non-voltage gated 1, beta subunit (Scnn1b) transgene in the club cells, which dictates increased ionic concentration of Na+ within the epithelial cells and establishes osmotic gradient to draw water from ASL (Mall et al., 2004).