Based on the molecular recognition between phospholipids on EV and ApoA-I mimetic peptides, They developed methotrexate (MTX)-loaded EVs functionalized with 4F-KLA-LDL peptide, which can target low-density lipoprotein (LDL) on GBM cells and enhance the transport of the pro-apoptotic peptide KLA and methotrexate (MTX) to U87 glioma cells. This evidence concerns the gene KL and central nervous system cancer.