Stratifying patients into patients with normal or elevated percentage of CD57+ CD8 T cells according to the criteria mentioned in the Methods section demonstrated an increased presence of splenomegaly at both time points (t1: p=0.042, t2: p=0.035) and status post-splenectomy only at first time point (p=0.045), whereas the association with CMV history and hematologic neoplasia was present only at the second timepoint (p=0.003 and p=0.035, respectively) in patients with elevated CD57+ CD8 T cells (Supplementary Table 8). The gene discussed is CD8A; the disease is Splenomegaly.