,25,26,27,28,29,30 Both oxPS and lysoPS are degraded by the PS lipase ABHD1231 and patients with ABHD12 loss-of-function mutations develop PHARC syndrome, a rare congenital neurodegenerative disease involving pro-inflammatory lysoPS and oxPS accumulation in the brain, enhanced microglial phagocytosis, and pathological neuroinflammation.32 Here, ABHD12 is linked to PHARC syndrome.