First, while this study demonstrated that AAV-mediated neuronal overexpression of the PS lipase ABHD12 ameliorates motor axon disease in the previously published Nmnat2V98M/R232Q mouse model of sarmopathy, this manipulation needs to be tested in more common disease models associated with SARM1 activation, such as chemotherapy-induced neuropathy or inherited conditions like CMT2A. This evidence concerns the gene ABHD12 and Charcot-Marie-Tooth disease type 2A1.