Under the condition of periodontitis, osteoclastogenesis was also stimulated by 5-HTP, which raised the RANKL/osteoprotegerin (OPG) ratio and the quantity of IL-6+ osteocytes, thereby exacerbating the loss of alveolar bone and worsening the microstructure [75]. The gene discussed is TNFRSF11B; the disease is periodontitis.