AHR and rheumatoid arthritis: Nevertheless, the importance of Trp metabolites derived from the microbiota is underscored by extensive research showing that these compounds, acting as agonists of AhR, perform an important function in managing immune disorders [211], which achieved relief by modulating the microbial community, preserving the intestinal barrier, balancing immunity, and bone impairment in individuals suffering from RA, efficiently bridging the connection between the gut and joints [212].