TGF-β1 can downregulate the expression and distribution of connexin 43, leading to abnormal electrical signal conduction between cardiomyocytes, an increase in the heterogeneity of myocardial electrical activity, and the easy formation of reentrant excitation, which in turn induces arrhythmia [13, 14]. This evidence concerns the gene TGFB1 and cardiac arrhythmia.