Indeed, MCP is the one chronic pain phenotype causally linked to Alzheimer’s disease dementia specifically, for which Aβ is the key pathology.12 Furthermore, we focused on assessment of Alzheimer’s disease pathology directly in post-mortem brain tissue whereas Bell et al. 45 and Sadlon et al. 46 relied on extracerebral measures of Aβ and tau, which do not directly reflect levels of Alzheimer’s disease pathology in the brain. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.