Our analyses also make use of post-mortem brain tissue to examine the association of MCP with primary indicators of Alzheimer’s disease pathology, including Aβ and tau tangles globally across Alzheimer’s disease-affected brain regions, and particularly in the hippocampus and entorhinal cortex—the most vulnerable sites of Alzheimer’s disease pathology.23 The gene discussed is MAPT; the disease is Alzheimer disease.