One of possible functions of TANs is the remodeling of the extracellular matrix through the secretion of proteases such as neutrophil elastase, matrix metalloproteinases and cathepsin G as well as promoting epithelial–mesenchymal transition via the release of reactive oxygen species (ROS) and cytokines such as IL-8, enhancing tumor cells invasiveness (20). The gene discussed is CTSG; the disease is neoplasm.