First, Lp(a) promotes atherosclerosis and thrombosis by facilitating atherosclerotic plaque formation through its cholesterol-rich LDL-like structure, while its Apo(a) component, which resembles plasminogen, competitively inhibits the fibrinolytic system, thereby enhancing thrombotic potential and increasing the risk of ACS recurrence (47–49). This evidence concerns the gene AOPEP and atherosclerosis.