In patients suffering with osteoporosis, SPARCL1-OC followed by HSP1IA-OC parathyroid oxyphil cells were highly clustered, while in non-osteoporosis patients CXCL10-PCC followed by S100A13-PCC parathyroid chief cells were highly clustered (Figures 4C, D). Here, SPARCL1 is linked to osteoporosis.