Both CRP and the other cytokines measured, as well as WBC, do correlate with each other as well as with measures of overweight and waist circumference in this dataset (Supplementary Table S1), indicating that, in this cohort, although there is a clear relationship between general systemic inflammation, increased body fat, and obesity (28), inflammatory parameters, measured contemporaneously, do not appear to influence Leydig-cell functional capacity as represented by circulating INSL3 concentration. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.