HMGB1 and diabetes mellitus: Diabetes did not alter the expression of HMGB1 and HSP70 in the adrenal glands of Swiss-Webster mice (Figure 1D, Supplementary Figure S1A, Supplementary Figure S1B and Supplementary Figure S1C); however, it increased the expression of TLR4 and TRIF (Figure 1E, Supplementary Figure S1D, Supplementary Figures S1E, F) compared to non-diabetic mice.