Besides, fibrate drugs are widely used for the treatment of hyperlipidemia; as peroxisomal ACOX‐1 is strongly induced by this kind of drug, we proposed that diabetic patients with severe obesity administered fibrate drugs might have a high risk of alcohol‐associated liver diseases when ingesting excessive alcohol, as hyperinduction of peroxisomal β‐oxidation will greatly enhance the turnover rate of ethanol and accelerate the onset and development of alcoholic fatty liver and related liver injury. This evidence concerns the gene ACOX1 and Obesity.