APP and Alzheimer disease: A study using a mouse model of Alzheimer's disease, involving mice that had mutated forms of both human amyloid precursor protein (APP) and the presenilin 1 gene, found that supplementing these mice with deuterated PUFAs for 5 months led to high levels of deuterated PUFA incorporation into arachidonic acid and docosahexaenoic acid in the brain, along with a reduction in the lipid peroxidation products, F2 isoprostanes and neuroprostanes.