TGFB1 and chronic kidney disease: Another study indicated that Drp1 deficiency could inhibit the activation and proliferation of TGF-β1-induced renal interstitial fibroblasts, whereas facilitate cell apoptosis, as well as reduce mitochondrial breakdown, ROS elevation, and glycolytic metastasis after TGF-β1 stimulation, which implied that Drp1 may be a therapeutic target for delaying the development of chronic kidney disease [59].