In this rationale, the study by Ma et al. indicated that stimulated TRAF6/PI3K/AKT signaling in ovariectomized rats is associated with overexpressed MDA and suppressed SOD and GSH, which subsequently encourages osteoclastogenesis and causes bone resorption as well as osteoporosis (Ma et al., 2018). The gene discussed is SOD1; the disease is osteoporosis.