When compared with SR and puerarin, polyphyllin VII’s antioxidant capability is highly potent, especially in inhibiting the TRAF6-Nox1-mediated ROS pathway, which makes it particularly effective for oxidative stress-induced bone resorption common in osteoporosis (Zhou et al., 2020; Yang et al., 2023). Here, TRAF6 is linked to osteoporosis.