NFKB1 and sleep disorder: Beyond their established use in sleep disorders, ramelteon alleviates experimental acute ocular inflammation via HIF-1Α/VEGF/E-NOS signaling (Usta Sofu et al., 2022), while agomelatine attenuates cisplatin-induced nephrotoxicity by suppressing NF-κB-driven inflammation (Dil et al., 2023).