Key circadian genes regulate vascular factors like vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS), which are crucial for endothelial function and vascular stability; disturbances in circadian rhythms impair endothelial function, increase vascular permeability, and lead to abnormal angiogenesis, collectively worsening both kidney and eye diseases (Bhatwadekar and Rameswara, 2020). The gene discussed is NOS3; the disease is eye disorder.