<b>Case Presentation:</b> In this case report, we describe the reclassification of a newly identified heterozygous <i>FBN1</i> variant, c.2686T > A, p.(Cys896Ser), to likely pathogenic in a Caucasian 21-year-old female patient presenting with abnormal anterior eye segment with superior bilateral ectopia lentis; joint pain affecting wrists, knees, and upper back; and mild thoracolumbar scoliosis. This evidence concerns the gene FBN1 and Thoracolumbar scoliosis.