HUWE1 and cask-related x-linked intellectual disability: The HECT E3 ligase HUWE1 is also genetically linked to XLID and plays an important role in the neuronal and glial differentiation of NPCs in mice (Zhao et al., 2008; Friez et al., 2016; Giles and Grill, 2020; Muthusamy et al., 2020).