In clinical settings, the levels of serum adropin were inversely associated with the presence of atherosclerosis, coronary artery disease, acute myocardial infarction, heart failure, atrial fibrillation, AKI, CKD, and diabetes mellitus [[31], [32], [33], [34], [35], [36]]. The gene discussed is ENHO; the disease is atrial fibrillation.