Our study has revealed that the levels of serum adropin were positively correlated with LVEF (r = 0.30; P = 0.001), HDL-C levels (r = 0.32; p = 0.018), creatinine (r = 0.23; p = 0.024) and inversely with a presence of atrial fibrillation (r = −0.28; P = 0.001), CKD (r = −0.30; P = 0.001), T2DM (r = −0.38; P = 0.001), HFrEF (r = −0.31; P = 0.001), LAVI (r = −0.34; P = 0.001), BMI (r = −0.32; P = 0.001), fasting glucose (r = −0.32; P = 0.012), HOMA-IR (r = −0.30; P = 0.012), UACR (r = −0.29; P = 0.001), triglyceride levels (r = −0.30; P = 0.010), NT-proBNP(r = −0.21; P = 0.026). The gene discussed is NPPB; the disease is atrial fibrillation.