However, predictive potencies of serum creatinine, natriuretic peptides, electrolytes, haematocrit retained to be uncertain in ADHF patients with lower risk and positive respond to decongestion [52,53].This is particularly important for patients hospitalized with ADHF and receiving optimal guideline-based HF therapy, including SGLT2 inhibitors, ARNI, beta-blockers and MRA, while these medications are frequently withheld during AKI because of concerns about worsening GFR and persistence of elevated creatinine [54,55]. Here, SLC5A2 is linked to acute kidney injury.