Among the PRRs, the cytoplasmic receptors RIG-I (retinoic acid-inducible 1) and MDA5 (melanoma differentiation-associated 5) play pivotal roles in the host’s antiviral response (Kato et al., 2006; Thoresen et al., 2021), confirming the innate immune activation following viral infection (Chibssa et al., 2021). The gene discussed is RIGI; the disease is viral infectious disease.