NR3C2 and Hyperkalemia: However, there was no dose-dependent difference in the risk of hyperkalemia compared with eplerenone, which may be attributed to its highly selective inhibitory effect, which stabilizes the risk of hyperkalemia (7).The reason for this phenomenon may be that finerenone, its structure, is highly specific for the regulation of MR activity and inhibits sodium reabsorption and enhances potassium retention by blocking the effect of MR in the distal convoluted tubule and collecting duct, resulting in increased risk of hyperkalemia (6).