For example, Hou et al. found METTL3-induced circ_0008345 can lead to the tumorigenesis of CRC via mediation of micRNA-182-5p/CYP1A2 axis (17); circPDIA3/miR-449a/XBP1 feedback loop could curb pyroptosis through suppressing palmitoylation of the GSDME-C domain to induce chemoresistance of CRC (18). The gene discussed is XBP1; the disease is colorectal carcinoma.