APEX1 can treat cancer by affecting ferroptosis has been reported in a variety of tumors (e.g., hepatocellular carcinoma (Du et al., 2024; Diao et al., 2024), gastric cancer (Zhao et al., 2023), osteosarcoma (Xiao et al., 2024), etc.). The gene discussed is APEX1; the disease is osteosarcoma.