Prasath found that Isoliensinine combined with platinum in the treatment of colorectal cancer enhanced ROS-mediated endogenous apoptosis by activating the MAPK/PI3K/AKT pathway (Manogaran et al., 2019), and he also found that cisplatin resistance was reversed in colorectal cancer stem cells (Manogaran et al., 2022). This evidence concerns the gene AKT1 and colorectal cancer.