The overactivation of the PI3K-Akt pathway has been closely associated with the development of various autoimmune diseases, such as autoimmune hepatitis (Wang et al., 2023b), psoriasis (Patel and Mohan, 2005), and rheumatoid arthritis (Malemud, 2015; Noguchi et al., 2008). Here, PIK3CG is linked to autoimmune hepatitis.