Several tumor suppressor genes and oncogenes (for example-tumor suppressor gene p53 and oncogene c-Myc) are regulated by CC, as well as the core CCGs are controlled by tumor suppressor genes and oncogenes, which are associated with malignancy and tumor onse (Huber et al., 2016; Shostak et al., 2016; Li, 2019). Here, CXCR1 is linked to neoplasm.