In addition, in U-87 and LN229 glioma cells, 1A-116 selectively suppressed activation of RAC1 to guanine exchange factors including T-lymphoma invasion and metastasis-inducing protein 1 via interacting with the Trp56 residue (Cardama et al., 2014; Langston et al., 2019). This evidence concerns the gene RAC1 and central nervous system cancer.