OLFML3 and neoplasm: Bmal1 plays an important role in regulating microglial immune function and cellular metabolism. The CLOCK:BMAL1 triggers microglial reprogramming through the HIF1α/OLFML3/LGMN axis. This microglial reprogramming can inhibit immune cells, mediate tumorigenesis and obtain an infiltrative phenotype. In addition to this, reprogrammed microglia signal back to the tumor cell via exosomes with miR-7239-3p to reduce Bmal1 and elevate Clock