Both REV-ERBα as well as REV-ERBβ have significant contributions in circadian rhythms, inflammation, tumorigenesis, and glucose as well as lipid metabolism, which play a role as the components associating the CC with the cellular metabolism. An elevated level of NR1D2 (REV-ERBβ) expression was found to correlate positively with glioma grades. Compared to healthy noncancerous astrocytes, increased levels of NR1D2 were found in glioblastoma multiforme cells. The gene discussed is NR1D1; the disease is glioblastoma.