TP53 and central nervous system cancer: After CC suppression, a decreased level of proliferation and apoptosis induction was detected in gliomas associated with a p53 complex upregulation, which indicates the anti-apoptotic modulation of Clock in gliomas. An opposite link was observed between the tumor-suppressive action of the Clock and hypoxia, which indicates that the Clock suppression in tumor cells increased survival and decreased microglial migration