RhoA/ROCK pathway is implicated in various diseases, including ovarian cancer (Wei et al., 2021), chronic headache (Jing et al., 2019), traumatic brain injury (Mulherkar and Tolias, 2020), Parkinson’s disease (Iyer et al., 2021), stroke (Lu et al., 2023)and other neurological disorders. This evidence concerns the gene RHOA and stroke disorder.