After plotting amplitude (Fig. 1B), we identified that PER3, CLOCK, NR1D1 and ARNTL, while retaining rhythmicity, displayed significant reductions in amplitude in myocytes from individuals with T2D compared to those with normal glucose tolerance (NGT), with fold changes of 0.26, 0.31, 0.22 and 0.71, respectively. This evidence concerns the gene CLOCK and type 2 diabetes mellitus.