HOXB5 and type 2 diabetes mellitus: Re-analysis of publicly available data (Gabriel et al., 2021) demonstrated that ARNTL, HOXB5, PER3, and TSSK6 had loss of rhythmicity or a differential circadian rhythmicity in skeletal muscle cells from people with T2D compared to healthy individuals matched for age and body mass index (BMI) (Fig. 1A).