Re-analysis of publicly available data (Gabriel et al., 2021) demonstrated that ARNTL, HOXB5, PER3, and TSSK6 had loss of rhythmicity or a differential circadian rhythmicity in skeletal muscle cells from people with T2D compared to healthy individuals matched for age and body mass index (BMI) (Fig. 1A). This evidence concerns the gene TSSK6 and type 2 diabetes mellitus.