LNPEP and nervous system disorder: This distinction is helpful for developing effectiveIRAP-targeted therapies, particularly for neurological disorders. Recent advancements have led to the discoveryof novel IRAP inhibitors,−, , , , , , ,  and improved our understanding of binding affinities and structuraldynamics.−, , ,  However, the molecular basis for IRAP’s contrasting behaviortoward these two peptides remains unclear.