HMOX1 and central nervous system cancer: Furthermore, our findings revealed a hallmark of the JAK–STAT signalling pathway (NES = 1.995, p = 0.011, FDR = 0.004) and the syndecan 1 pathway in gliomas expressing HMOX1 (NES = 2.405, p < 0.001, FDR < 0.001) (Figure 6B,C).