In an idiopathic pulmonary fibrosis (IPF) case, it was found that PI3K signal transduction enzyme catalyses PIP2 to PIP3, then further induces TGFβ for cell proliferation, collagen production and differentiation into myofibroblast, causing IPF [18]. This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.