A similar finding was observed in experimental models of Heymann nephritis, where the administration of a neutralizing antibody against heparanase or the heparanase inhibitor PI‐88 prevented the progression of glomerulonephritis (Levidiotis, Freeman, Punler, et al. 2004; Levidiotis, Freeman, Tikellis, et al. 2004). This evidence concerns the gene HPSE and glomerulonephritis.